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Article

TERT rs2736100T/G polymorphism upregulates interleukin 6 expression in non-small cell lung cancer especially in adenocarcinoma.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine - 1 May 2014

Wang Fuxia, Fu Ping, Pang Yixin, Liu Chengxiang, Shao Zhulin, Zhu Jingyan, Li Jie, Wang Ti, Zhang Xia, Liu Jie

Abstract excerpt

Telomerase reverse transcriptase (TERT) is the catalytic component of telomerase, especially the rate-limiting determinant of telomerase activity. Accumulating evidence has suggested that TERT could modulate the expression of numerous genes including interleukin 6 (IL-6), an important cytokine for the development of lung cancer. It has been reported that TERT polymorphism rs2736100T/G is associated with increased...

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Identifiers

PMID: 24420154
DOI: 10.1007/s13277-014-1611-z

Genes

TERT

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