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Article

Characterization of a novel IMP-28 metallo-β-lactamase from a Spanish Klebsiella oxytoca clinical isolate.

Antimicrobial agents and chemotherapy - 1 Aug 2012

Pérez-Llarena Francisco José, Fernández Ana, Zamorano Laura, Kerff Frédéric, Beceiro Alejandro, Aracil Belén, Cercenado Emilia, Miro Elisenda, Oliver Antonio, Oteo Jesús, Navarro Ferran, Bou Germán

Abstract excerpt

An isolate of Klebsiella oxytoca carrying a novel IMP metallo-β-lactamase was discovered in Madrid, Spain. The bla(IMP-28) gene is part of a chromosomally located class I integron. The IMP-28 k(cat)/K(m) values for ampicillin, ceftazidime, and cefepime and, to a lesser extent, imipenem and meropenem, are clearly lower than those of IMP-1. The His306Gln mutation may induce important modifications of the L3 loop...

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Identifiers

PMID: 22668859
DOI: 10.1128/AAC.00776-12
PMCID: PMC3421603

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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