Using prior information from the medical literature in GWAS of oral cancer identifies novel susceptibility variant on chromosome 4--the AdAPT method.

doi:10.1371/journal.pone.0036888

Article

Using prior information from the medical literature in GWAS of oral cancer identifies novel susceptibility variant on chromosome 4--the AdAPT method.

PloS one - 1 Jan 2012

Johansson Mattias, Roberts Angus, Chen Dan, Li Yaoyong, Delahaye-Sourdeix Manon, Aswani Niraj, Greenwood Mark A, Benhamou Simone, Lagiou Pagona, Holcátová Ivana, Richiardi Lorenzo, Kjaerheim Kristina, Agudo Antonio, Castellsagué Xavier, Macfarlane Tatiana V, Barzan Luigi, Canova Cristina, Thakker Nalin S, Conway David I, Znaor Ariana, Healy Claire M, Ahrens Wolfgang, Zaridze David, Szeszenia-Dabrowska Neonilia, Lissowska Jolanta, Fabiánová Eleonóra, Mates Ioan Nicolae, Bencko Vladimir, Foretova Lenka, Janout Vladimir, Curado Maria Paula, Koifman Sergio, Menezes Ana, Wünsch-Filho Victor, Eluf-Neto Jose, Boffetta Paolo, Franceschi Silvia, Herrero Rolando, Fernandez Garrote Leticia, Talamini Renato, Boccia Stefania, Galan Pilar, Vatten Lars, Thomson Peter, Zelenika Diana, Lathrop Mark, Byrnes Graham, Cunningham Hamish, Brennan Paul, Wakefield Jon, McKay James D

Abstract excerpt

BACKGROUND: Genome-wide association studies (GWAS) require large sample sizes to obtain adequate statistical power, but it may be possible to increase the power by incorporating complementary data. In this study we investigated the feasibility of automatically retrieving information from the medical literature and leveraging this information in GWAS. METHODS: We developed a method that searches through PubMed...

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