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Amniotic Fluid Stem Cells Restore the Muscle Cell Niche in a <i>HSA‐Cre</i> , <i> Smn <sup>F7/F7</sup> </i> Mouse Model

29 May 2012

Abstract excerpt

Mutations in the survival of motor neuron gene (SMN1) are responsible for spinal muscular atrophy, a fatal neuromuscular disorder. Mice carrying a homozygous deletion of Smn exon 7 directed to skeletal muscle (HSA-Cre, Smn(F7/F7) mice) present clinical features of human muscular dystrophies for which new therapeutic approaches are highly warranted. Herein we demonstrate that tail vein transplantation of mouse...

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PMID: 22644669
DOI: 10.1002/stem.1134

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