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Article

Bone morphogenetic proteins differentially regulate pigmentation in human skin cells

1 Jan 2012

Abstract excerpt

Bone morphogenetic proteins (BMPs) are a large family of multi-functional secreted signalling molecules. Previously BMP2/4 were shown to inhibit skin pigmentation by downregulating tyrosinase expression and activity in epidermal melanocytes. However, a possible role for other BMP family members and their antagonists in melanogenesis has not yet been explored. In this study we show that BMP4 and BMP6, from two...

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PMID: 22641693
DOI: 10.1242/jcs.102038

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