Article
Detection of transcriptional triggers in the dynamics of microbial growth: application to the respiratorily versatile bacterium Shewanella oneidensis.
Nucleic acids research - 1 Aug 2012
Beg Qasim K, Zampieri Mattia, Klitgord Niels, Collins Sara B, Altafini Claudio, Serres Margrethe H, Segrè Daniel
Abstract excerpt
The capacity of microorganisms to respond to variable external conditions requires a coordination of environment-sensing mechanisms and decision-making regulatory circuits. Here, we seek to understand the interplay between these two processes by combining high-throughput measurement of time-dependent mRNA profiles with a novel computational approach that searches for key genetic triggers of transcriptional...
Topics
- Algorithms
- Anti-Bacterial Agents
- Culture Media
- Escherichia coli
- Gene Expression Profiling
- Gene Expression Regulation, Bacterial
- Phenotype
- Shewanella
- Transcription, Genetic