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Article

Septal localization of the Mycobacterium tuberculosis MtrB sensor kinase promotes MtrA regulon expression.

The Journal of biological chemistry - 6 Jul 2012

Plocinska Renata, Purushotham Gorla, Sarva Krishna, Vadrevu Indumathi S, Pandeeti Emmanuel V P, Arora Naresh, Plocinski Przemyslaw, Madiraju Murty V, Rajagopalan Malini

Abstract excerpt

The mechanisms responsible for activation of the MtrAB two-component regulatory signal transduction system, which includes sensor kinase MtrB and response regulator MtrA, are unknown. Here, we show that an MtrB-GFP fusion protein localized to the cell membrane, the septa, and the poles in Mycobacterium tuberculosis and Mycobacterium smegmatis. This localization was independent of MtrB phosphorylation status but...

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Identifiers

PMID: 22610443
DOI: 10.1074/jbc.M112.346544
PMCID: PMC3390665

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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