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Article

Contrasting patterns of selection acting on MHC class I and class II DRB genes in the Alpine marmot (Marmota marmota).

Journal of evolutionary biology - 1 Aug 2012

Kuduk K, Johanet A, Allainé D, Cohas A, Radwan J

Abstract excerpt

The major histocompatibility complex (MHC) genes code for proteins that play a critical role in the immune system response. The MHC genes are among the most polymorphic genes in vertebrates, presumably due to balancing selection. The two MHC classes appear to differ in the rate of evolution, but the reasons for this variation are not well understood. Here, we investigate the level of polymorphism and the...

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Share to Evolution, Molecular
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Share to Genes, MHC Class I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class II

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Share to Polymorphism, Genetic

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Source

Identifiers

PMID: 22594882
DOI: 10.1111/j.1420-9101.2012.02537.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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