Article
Hsp90 inhibition overcomes HGF-triggering resistance to EGFR-TKIs in EGFR-mutant lung cancer by decreasing client protein expression and angiogenesis.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jul 2012
Koizumi Hitomi, Yamada Tadaaki, Takeuchi Shinji, Nakagawa Takayuki, Kita Kenji, Nakamura Takahiro, Matsumoto Kunio, Suda Kenichi, Mitsudomi Tetsuya, Yano Seiji
Abstract excerpt
INTRODUCTION: The three major clinically relevant mechanisms of acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in EGFR mutant lung cancer are a second mutation in the EGFR gene (T790M), Met amplification, and increased expression of hepatocyte growth factor (HGF). Heat shock protein90 (Hsp90) is a 90 kDa molecular chaperone for proteins that include EGFR, Met, and...
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