Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Direct molecular detection and genotyping of Borrelia burgdorferi from whole blood of patients with early Lyme disease.

PloS one - 1 Jan 2012

Eshoo Mark W, Crowder Christopher C, Rebman Alison W, Rounds Megan A, Matthews Heather E, Picuri John M, Soloski Mark J, Ecker David J, Schutzer Steven E, Aucott John N

Abstract excerpt

Direct molecular tests in blood for early Lyme disease can be insensitive due to low amount of circulating Borrelia burgdorferi DNA. To address this challenge, we have developed a sensitive strategy to both detect and genotype B. burgdorferi directly from whole blood collected during the initial patient visit. This strategy improved sensitivity by employing 1.25 mL of whole blood, a novel pre-enrichment of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Bacterial
Share to Borrelia burgdorferi

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Bacterial

Share to Follow-Up Studies

Share to Genotype

Share to Lyme Disease

Share to Polymerase Chain Reaction

Share to Vector-borne infectious diseases

Source

Open in PubMed Open full text

Identifiers

PMID: 22590620
DOI: 10.1371/journal.pone.0036825
PMCID: PMC3348129

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Direct molecular detection and genotyping of Borrelia burgdorferi from whole blood of patients with early Lyme disease.PMID 22590620Read ↗

Quantitative Detection of Borrelia burgdorferi sensu lato in Erythema Migrans Skin Lesions Using Internally Controlled Duplex Real Time PCRSemantic proximity Read ↗

Development of a sensitive molecular diagnostic assay for detecting Borrelia burgdorferi DNA from the blood of Lyme disease patients by digital PCRSemantic proximity Read ↗

Overcoming the Challenges of Lyme Disease Diagnosis: The Role of Phage-based TestingSemantic proximity Read ↗

Borrelia burgdorferi genetic markers and disseminated disease in patients with early Lyme disease.Semantic proximity Read ↗

Investigation of Borrelia burgdorferi genotypes in Australia obtained from erythema migrans tissueSemantic proximity Read ↗

Multiplexed single-tier immunoassay for improved Lyme disease diagnosis across all disease stagesSemantic proximity Read ↗

Development of a sensitive molecular diagnostic assay for detecting <i>Borrelia burgdorferi</i> DNA from blood of Lyme disease patients by digital PCRSemantic proximity Read ↗

Sensitive multiplex PCR assay to differentiate Lyme spirochetes and emerging pathogens Anaplasma phagocytophilum and Babesia microtiSemantic proximity Read ↗

PCR in laboratory diagnosis of human Borrelia burgdorferi infectionsSemantic proximity Read ↗

Differences in Genotype, Clinical Features, and Inflammatory Potential of Borrelia burgdorferi sensu stricto Strains from Europe and the United States.Semantic proximity Read ↗

Sanger Sequencing Revealed <em>Borrelia burgdorferi</em> with FlaB Paralogs Causing Spirochetemia in Early Localized Lyme DiseaseSemantic proximity Read ↗

Serologic Response to Borrelia Antigens Varies with Clinical Phenotype in Children and Young Adults with Lyme Disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.