Article
Borrelia burgdorferi genetic markers and disseminated disease in patients with early Lyme disease.
Journal of clinical microbiology - 1 Dec 2006
Jones Kathryn L, Glickstein Lisa J, Damle Nitin, Sikand Vijay K, McHugh Gail, Steere Allen C
Abstract excerpt
Three genetic markers of Borrelia burgdorferi have been associated with disseminated disease: the OspC type, the 16S-23S rRNA intergenic spacer type (RST), and vlsE. Here, we modified previous methods so as to identify the three markers by PCR and restriction fragment length polymorphism in parallel, analyzed B. burgdorferi isolates from erythema migrans (EM) skin lesions in 91 patients, and correlated the...
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