Article
Resveratrol stimulates cortisol biosynthesis by activating SIRT-dependent deacetylation of P450scc.
Endocrinology - 1 Jul 2012
Li Donghui, Dammer Eric B, Sewer Marion B
Abstract excerpt
In the human adrenal cortex, cortisol is synthesized from cholesterol by members of the cytochrome P450 superfamily and hydroxysteroid dehydrogenases. Both the first and last steps of cortisol biosynthesis occur in mitochondria. Based on our previous findings that activation of ACTH signaling changes the ratio of nicotinamide adenine dinucleotide (NAD) phosphate to reduced NAD phosphate in adrenocortical cells,...
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