Article
A novel method to select informative SNPs and their application in genetic association studies.
IEEE/ACM transactions on computational biology and bioinformatics - 1 Jan 2000
Liao Bo, Li Xiong, Zhu Wen, Cao Zhi
Abstract excerpt
The association studies between complex diseases and single nucleotide polymorphisms (SNPs) or haplotypes have recently received great attention. However, these studies are limited by the cost of genotyping all SNPs. Therefore, it is essential to find a small subset of tag SNPs representing the rest of the SNPs. The presence of linkage disequilibrium between tag SNPs and the disease variant (genotyped or not),...
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