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Article

Zinc metalloproteinase ProA directly activates Legionella pneumophila PlaC glycerophospholipid:cholesterol acyltransferase.

The Journal of biological chemistry - 6 Jul 2012

Lang Christina, Rastew Elena, Hermes Björn, Siegbrecht Enrico, Ahrends Robert, Banerji Sangeeta, Flieger Antje

Abstract excerpt

Enzymes secreted by Legionella pneumophila, such as phospholipases A (PLAs) and glycerophospholipid:cholesterol acyltransferases (GCATs), may target host cell lipids and therefore contribute to the establishment of Legionnaires disease. L. pneumophila possesses three proteins, PlaA, PlaC, and PlaD, belonging to the GDSL family of lipases/acyltransferases. We have shown previously that PlaC is the major GCAT...

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Identifiers

PMID: 22582391
DOI: 10.1074/jbc.M112.346387
PMCID: PMC3390623

Genes

GCAT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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