Article
Whole genome sequencing and evolutionary analysis of human papillomavirus type 16 in central China.
PloS one - 1 Jan 2012
Sun Min, Gao Lei, Liu Ying, Zhao Yiqiang, Wang Xueqian, Pan Yaqi, Ning Tao, Cai Hong, Yang Haijun, Zhai Weiwei, Ke Yang
Abstract excerpt
Human papillomavirus type 16 plays a critical role in the neoplastic transformation of cervical cancers. Molecular variants of HPV16 existing in different ethnic groups have shown substantial phenotypic differences in pathogenicity, immunogenicity and tumorigenicity. In this study, we sequenced the entire HPV16 genome of 76 isolates originated from Anyang, central China. Phylogenetic analysis of these sequences...
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