Article
Depression and anxiety symptoms among women who carry the FMR1 premutation: impact of raising a child with fragile X syndrome is moderated by CRHR1 polymorphisms.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jul 2012
Hunter Jessica Ezzell, Leslie Mary, Novak Gloria, Hamilton Debra, Shubeck Lisa, Charen Krista, Abramowitz Ann, Epstein Michael P, Lori Adriana, Binder Elisabeth, Cubells Joseph F, Sherman Stephanie L
Abstract excerpt
The fragile X mental retardation gene, FMR1, contains a polymorphic CGG repeat in the 5'-untranslated region of exon 1. Once unstable, this repeat is capable of expansion across generations. Women who carry a premutation allele (55-199 repeats) are at risk of passing on a full mutation allele (>200 repeats) to their offspring. A full mutation leads to the most common form of inherited intellectual disability,...
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