No association between FMR1 premutation and either ADHD or anxiety in 53,707 women undergoing genetic testing for family planning purposes.

doi:10.1016/j.gim.2025.101428

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Article

No association between FMR1 premutation and either ADHD or anxiety in 53,707 women undergoing genetic testing for family planning purposes.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jul 2025

Klausner Liraz, Carmi Shai, Ben-Shachar Shay, Lev-El Halabi Noa, Basel-Salmon Lina, Brabbing-Goldstein Dana

Abstract excerpt

PURPOSE: FMR1 premutation has been inconsistently associated with neuropsychiatric phenotypes, possibly because of ascertainment bias. We investigated the association between FMR1 premutation and attention deficit hyperactivity disorder (ADHD), anxiety, and other psychiatric disorders in large-scale population-based genetic carrier screening data. METHODS: We defined premutation as having 58 to 200 CGG repeats....

Read the complete abstract on PubMed

Topics

Humans
Female
Fragile X Messenger Ribonucleoprotein 1
Attention Deficit Disorder with Hyperactivity
Adult

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Anxiety

Genetic Testing

Family Planning Services

Primary Ovarian Insufficiency

Mutation

Young Adult

Phenotype

Source

Open in PubMed

Identifiers

PMID: 40196935
DOI: 10.1016/j.gim.2025.101428

Genes

FMR1

Provenance

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