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Article

Depression Symptom Trajectories in Mothers With the FMR1 Premutation Vary by CGG Repeat Length: A Longitudinal Study of 73 Women Spanning 20-75 Years of Age.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Oct 2025

Klusek Jessica, Jenner Lauren, Hogan Abigail L, Friedman Laura, Berry-Kravis Elizabeth, Tassone Flora, Adayev Tatyana, Fairchild Amanda J, Roberts Jane E

Abstract excerpt

Women with the FMR1 premutation (FXpm) are at heightened genetic vulnerability for depression, with risk compounded by the stressors of parenting a disabled child. Although risk factors persist as FXpm women age, depression in FXpm mothers during midlife and old age is poorly characterized. This study used an accelerated longitudinal design to capture the trajectory of depressive symptoms in 73 FXpm mothers...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40418066
DOI: 10.1002/ajmg.b.33033
PMCID: PMC12355380

Genes

FMR1

Provenance

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