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Article

Developmental trajectory and environmental moderation of the effect of ALDH2 polymorphism on alcohol use.

Alcoholism, clinical and experimental research - 1 Nov 2012

Irons Daniel E, Iacono William G, Oetting William S, McGue Matt

Abstract excerpt

BACKGROUND: In the aldehyde dehydrogenase 2 (ALDH2) gene, the ALDH2*2 allele, prevalent in East Asian populations, encodes an enzyme with severely reduced activity, thereby disrupting the normal metabolism of alcohol. Possession of the ALDH2*2 allele has been repeatedly shown to be associated wit...

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Identifiers

PMID: 22563891
DOI: 10.1111/j.1530-0277.2012.01809.x
PMCID: PMC3416945

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22563891-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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