Article
Developmental trajectory and environmental moderation of the effect of ALDH2 polymorphism on alcohol use.
Alcoholism, clinical and experimental research - 1 Nov 2012
Irons Daniel E, Iacono William G, Oetting William S, McGue Matt
Abstract excerpt
BACKGROUND: In the aldehyde dehydrogenase 2 (ALDH2) gene, the ALDH2*2 allele, prevalent in East Asian populations, encodes an enzyme with severely reduced activity, thereby disrupting the normal metabolism of alcohol. Possession of the ALDH2*2 allele has been repeatedly shown to be associated with lower risk for alcohol dependence and reduced alcohol use. However, relatively few studies have considered whether...
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