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Article

Estrogen receptor-α mediates gene expression changes and growth response in ovarian cancer cells exposed to estrogen

1 Dec 2005

Abstract excerpt

Estrogens play a significant role in the development, growth, invasion and metastasis of ovarian tumors. The transcriptional program regulated by 17beta-estradiol (E(2)) in human ovarian cancer cell lines was analyzed using cDNA microarrays containing 1200 cancer-related genes. Twenty-eight transcripts had at least a threefold change in expression in E(2)-treated PEO1 ovarian carcinoma cells compared with...

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Share to Cytokine Signaling Pathways and Interactions
Share to Estrogen and related hormone effects
Share to Reproductive System and Pregnancy

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PMID: 16322326
DOI: 10.1677/erc.1.01039

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