Article
Effect of zinc on human IgG1 and its FcγR interactions.
Immunology letters - 30 Mar 2012
Sibéril Sophie, Ménez Renée, Jorieux Sylvie, de Romeuf Christophe, Bourel Dominique, Fridman Wolf-Herman, Ducancel Frédéric, Stura Enrico A, Teillaud Jean-Luc
Abstract excerpt
In the present study, we show that histidines 310 and 435 at the CH2-CH3 interface of the Fc portion of human IgG1 can coordinate a Zn2+ and participate in the control of the CH2-CH2 interdomain opening. Structures obtained in the absence of Zn2+ have a reduced interdomain gap that likely hamper...
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