Article
Nonfunction of the ECT2 gene may cause renal tubulointerstitial injury leading to focal segmental glomerulosclerosis.
Clinical and experimental nephrology - 1 Dec 2012
Izu Akane, Sugimoto Keisuke, Fujita Shinsuke, Nishi Hitomi, Takemura Yutaka, Okada Mitsuru, Takemura Tsukasa
Abstract excerpt
BACKGROUND: Secondary focal segmental glomerulosclerosis (FSGS) follows congenital or acquired tubulointerstitial alterations such as in Dent's disease, Lowe syndrome, and reflux nephropathy. Failure of adequate regeneration after tubulointerstitial injury, or abnormal tubulogenesis, can disturb intrarenal blood circulation, causing excessive glomerular filtration. The epithelial cell-transforming sequence 2 gene...
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