Article
Common genetic variation at BARD1 is not associated with breast cancer risk in BRCA1 or BRCA2 mutation carriers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 2011
Spurdle Amanda B, Marquart Louise, McGuffog Lesley, Healey Sue, Sinilnikova Olga, Wan Fei, Chen Xiaoqing, Beesley Jonathan, Singer Christian F, Dressler Anne-Catharine, Gschwantler-Kaulich Daphne, Blum Joanne L, Tung Nadine, Weitzel Jeff, Lynch Henry, Garber Judy, Easton Douglas F, Peock Susan, Cook Margaret, Oliver Clare T, Frost Debra, Conroy Don, Evans D Gareth, Lalloo Fiona, Eeles Ros, Izatt Louise, Davidson Rosemarie, Chu Carol, Eccles Diana, Selkirk Christina G, Daly Mary, Isaacs Claudine, Stoppa-Lyonnet Dominique, Sinilnikova Olga M, Buecher Bruno, Belotti Muriel, Mazoyer Sylvie, Barjhoux Laure, Verny-Pierre Carole, Lasset Christine, Dreyfus Hélène, Pujol Pascal, Collonge-Rame Marie-Agnès, Rookus Matti A, Verhoef Senno, Kriege Mieke, Hoogerbrugge Nicoline, Ausems Margreet G E M, van Os Theo A, Wijnen Juul, Devilee Peter, Meijers-Heijboer Hanne E J, Blok Marinus J, Heikkinen Tuomas, Nevanlinna Heli, Jakubowska Anna, Lubinski Jan, Huzarski Tomasz, Byrski Tomasz, Durocher Francine, Couch Fergus J, Lindor Noralane M, Wang Xianshu, Thomassen Mads, Domchek Susan, Nathanson Kate, Caligo Ma, Jernström Helena, Liljegren Annelie, Ehrencrona Hans, Karlsson Per, Ganz Patricia A, Olopade Olufunmilayo I, Tomlinson Gail, Neuhausen Susan, Antoniou Antonis C, Chenevix-Trench Georgia, Rebbeck Timothy R
Abstract excerpt
BACKGROUND: Inherited BRCA1 and BRCA2 (BRCA1/2) mutations confer elevated breast cancer risk. Knowledge of factors that can improve breast cancer risk assessment in BRCA1/2 mutation carriers may improve personalized cancer prevention strategies. METHODS: A cohort of 5,546 BRCA1 and 2,865 BRCA2 mutation carriers was used to evaluate risk of breast cancer associated with BARD1 Cys557Ser. In a second nonindependent...
