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Article

Nitrogen regulation in Aspergillus: are two fingers better than one?

Gene - 30 Oct 1990

Caddick M X, Arst H N

Abstract excerpt

The areA gene, mediating nitrogen metabolite repression in Aspergillus nidulans, encodes a positive-acting regulatory protein with a single putative DNA-binding 'zinc finger' which is remarkably similar to the two 'zinc fingers' of the major regulatory protein of vertebrate erythroid cells (GF-1/Eryf1/NF-E1). The areA-300 mutation alters the specificity of gene activation in that it elevates expression of certain...

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PMID: 2253884
DOI: 10.1016/0378-1119(90)90422-n

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Nitrogen regulation in Aspergillus: are two fingers better than one?PMID 2253884Read ↗

Genetic and molecular characterization of murine GATA-1 in Aspergillus defines a critical role for the N-terminal finger.Semantic proximity Read ↗

Mutational analysis of AREA, a transcriptional activator mediating nitrogen metabolite repression in Aspergillus nidulans and a member of the "streetwise" GATA family of transcription factors.Semantic proximity Read ↗

C-terminal truncation of the transcriptional activator encoded by areA in Aspergillus nidulans results in both loss-of-function and gain-of-function phenotypes.Semantic proximity Read ↗

Role of the regulatory gene areA of Aspergillus oryzae in nitrogen metabolism.Semantic proximity Read ↗

The Aspergillus nidulans GATA transcription factor gene areB encodes at least three proteins and features three classes of mutation.Semantic proximity Read ↗

Deletion and overexpression of the Aspergillus nidulans GATA factor AreB reveals unexpected pleiotropy.Semantic proximity Read ↗

The TamA protein fused to a DNA-binding domain can recruit AreA, the major nitrogen regulatory protein, to activate gene expression in Aspergillus nidulans.Semantic proximity Read ↗

Multiple nuclear localization signals mediate nuclear localization of the GATA transcription factor AreA.Semantic proximity Read ↗

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arcA, the regulatory gene for the arginine catabolic pathway in Aspergillus nidulans.Semantic proximity Read ↗

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Subtle hydrophobic interactions between the seventh residue of the zinc finger loop and the first base of an HGATAR sequence determine promoter-specific recognition by the Aspergillus nidulans GATA factor AreA.Semantic proximity Read ↗

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