Article
High-resolution genetic mapping with pooled sequencing.
BMC bioinformatics - 19 Apr 2012
Edwards Matthew D, Gifford David K
Abstract excerpt
BACKGROUND: Modern genetics has been transformed by high-throughput sequencing. New experimental designs in model organisms involve analyzing many individuals, pooled and sequenced in groups for increased efficiency. However, the uncertainty from pooling and the challenge of noisy sequencing data demand advanced computational methods. RESULTS: We present MULTIPOOL, a computational method for genetic mapping in...
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