Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The p250GAP gene is associated with risk for schizophrenia and schizotypal personality traits.

PloS one - 1 Jan 2012

Ohi Kazutaka, Hashimoto Ryota, Nakazawa Takanobu, Okada Takeya, Yasuda Yuka, Yamamori Hidenaga, Fukumoto Motoyuki, Umeda-Yano Satomi, Iwase Masao, Kazui Hiroaki, Yamamoto Tadashi, Kano Masanobu, Takeda Masatoshi

Abstract excerpt

BACKGROUND: Hypofunction of the glutamate N-Methyl-d-aspartate (NMDA) receptor has been implicated in the pathophysiology of schizophrenia. p250GAP is a brain-enriched NMDA receptor-interacting RhoGAP. p250GAP is involved in spine morphology, and spine morphology has been shown to be altered in the post-mortem brains of patients with schizophrenia. Schizotypal personality disorder has a strong familial...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTPase-Activating Proteins

Share to Linkage Disequilibrium

Share to Schizophrenia

Share to Schizotypal Personality Disorder

Share to Surveys and Questionnaires

Source

Open in PubMed Open full text

Identifiers

PMID: 22530067
DOI: 10.1371/journal.pone.0035696
PMCID: PMC3329470

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The p250GAP gene is associated with risk for schizophrenia and schizotypal personality traits.PMID 22530067Read ↗

Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene.Semantic proximity Read ↗

Genetic variation in the schizophrenia-risk gene neuregulin1 correlates with personality traits in healthy individuals.Semantic proximity Read ↗

Neuregulin 1 gene and variations in perceptual aberration of schizotypal personality in adolescents.Semantic proximity Read ↗

Meta-analysis of genome-wide SNP- and pathway-based associations for facets of neuroticism.Semantic proximity Read ↗

Familial aggregation of schizotypy in schizophrenia-spectrum disorders and its relation to clinical and neurodevelopmental characteristics.Semantic proximity Read ↗

The genome-wide associated candidate gene ZNF804A and psychosis-proneness: Evidence of sex-modulated association.Semantic proximity Read ↗

Genome-wide association study of the five-factor model of personality in young Korean women.Semantic proximity Read ↗

Cortical and Subcortical Neuroanatomical Signatures of Schizotypy in 3,004 Individuals Assessed in a Worldwide ENIGMA StudySemantic proximity Read ↗

Intelligence as proxy phenotype providing insight into the heterogeneity of schizophreniaSemantic proximity Read ↗

The genetics of schizophrenia.Semantic proximity Read ↗

A genome-wide investigation into the underlying genetic architecture of personality traits and overlap with psychopathologySemantic proximity Read ↗

A common variant of the NOTCH4 gene modulates functional connectivity of the occipital cortex and its relationship with schizotypal traits.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.