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Article

Genome-wide gene expression analysis implicates the immune response and lymphangiogenesis in the pathogenesis of fetal chylothorax.

PloS one - 1 Jan 2012

Yeang Chen-Hsiang, Ma Gwo-Chin, Shih Jin-Chung, Yang Yu-Shih, Chen Chih-Ping, Chang Shun-Ping, Wu Sheng-Hai, Liu Chin-San, Kuo Shou-Jen, Chou Hung-Chieh, Hwu Wuh-Liang, Cameron Alan D, Ginsberg Norman A, Lin Yi-Shing, Chen Ming

Abstract excerpt

Fetal chylothorax (FC) is a rare condition characterized by lymphocyte-rich pleural effusion. Although its pathogenesis remains elusive, it may involve inflammation, since there are increased concentrations of proinflammatory mediators in pleural fluids. Only a few hereditary lymphedema-associated gene loci, e.g. VEGFR3, ITGA9 and PTPN11, were detected in human fetuses with this condition; these cases had a...

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Source

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Identifiers

PMID: 22529953
DOI: 10.1371/journal.pone.0034901
PMCID: PMC3329545

Genes

ITGA9
PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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