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Article

DNA methyltransferases 1 and 3b expression in Huh-7 cells expressing HCV core protein of different genotypes.

Digestive diseases and sciences - 1 Jun 2012

Benegiamo Giorgia, Vinciguerra Manlio, Mazzoccoli Gianluigi, Piepoli Ada, Andriulli Angelo, Pazienza Valerio

Abstract excerpt

BACKGROUND: Hepatitis C virus infects ~3% of the population and it is a risk factor for hepatocarcinogenesis. The epigenetic mechanisms of HCV-induced hepatocyte transformation towards malignancy in this context are unclear. AIMS: The purpose of this study was to evaluate the effect of HCV core proteins of different genotypes on DNA methyltransferases (DNMTs) induction. MATERIALS/METHODS: We investigated DNMT1,...

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Source

Identifiers

PMID: 22526584
DOI: 10.1007/s10620-012-2160-1

Genes

CDH1
DNMT1
SIRT1
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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