Article
COL4A1 mutations in patients with sporadic late-onset intracerebral hemorrhage.
Annals of neurology - 1 Apr 2012
Weng Yi-Chinn, Sonni Akshata, Labelle-Dumais Cassandre, de Leau Michelle, Kauffman W Berkeley, Jeanne Marion, Biffi Alessandro, Greenberg Steven M, Rosand Jonathan, Gould Douglas B
Abstract excerpt
OBJECTIVE: Mutations in the type IV collagen alpha 1 gene (COL4A1) cause dominantly inherited cerebrovascular disease. We seek to determine the extent to which COL4A1 mutations contribute to sporadic, nonfamilial, intracerebral hemorrhages (ICHs). METHODS: We sequenced COL4A1 in 96 patients with sporadic ICH. The presence of putative mutations was tested in 145 ICH-free controls. The effects of rare coding...
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