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Article

Late-onset intracerebral hemorrhage associated with COL4A1 variants: clinical and genetic perspectives.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 3 Jan 2026

Zhuang Xinting, Xu Shuyan, Chen Chaohan, Wang Ying, Hu Fangwei, Cai Bin

Abstract excerpt

BACKGROUND: Pathogenic variants in the COL4A1 gene, which encodes a key structural component of the vascular basement membrane, compromise vascular integrity and contribute to a broad spectrum of cerebrovascular disorders. COL4A1-related intracerebral hemorrhage (ICH) demonstrates a distinct bimodal age distribution, characterized by early-onset (perinatal/childhood) and late-onset (adulthood)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41484600
DOI: 10.1007/s10072-025-08611-y

Genes

COL4A1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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