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Article

Down-regulation of NLRP3 inflammasome in gingival fibroblasts by subgingival biofilms: Involvement of <i>Porphyromonas gingivalis</i>

20 Apr 2012

Abstract excerpt

Recognition of pathogen-associated molecular patterns that activate IL-1β is regulated by inflammasomes, predominantly of the nucleotide-binding oligomerization domain-like receptor (NLR) family. NLRP3 inflammasome is involved in the innate immune responses in periodontal disease. This is an inflammatory condition that destroys the tooth-supporting (periodontal) tissues, initiated by the subgingival formation of...

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PMID: 22522430
DOI: 10.1177/1753425912444767

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