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Article

Global tyrosine kinome profiling of human thyroid tumors identifies Src as a promising target for invasive cancers.

Biochemical and biophysical research communications - 11 May 2012

Cho Nancy L, Lin Chi-Iou, Du Jinyan, Whang Edward E, Ito Hiromichi, Moore Francis D, Ruan Daniel T

Abstract excerpt

BACKGROUND: Novel therapies are needed for the treatment of invasive thyroid cancers. Aberrant activation of tyrosine kinases plays an important role in thyroid oncogenesis. Because current targeted therapies are biased toward a small subset of tyrosine kinases, we conducted a study to reveal novel therapeutic targets for thyroid cancer using a bead-based, high-throughput system. METHODS: Thyroid tumors and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22521882
DOI: 10.1016/j.bbrc.2012.04.034

Genes

ABL1
BTK
EGFR
GRB2
HCK
PTK6
SRC
TNK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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