Article
Asthma treatment outcome in children is associated with vascular endothelial growth factor A (VEGFA) polymorphisms.
Molecular diagnosis & therapy - 1 Jun 2012
Balantic Mateja, Rijavec Matija, Skerbinjek Kavalar Maja, Suskovic Stanislav, Silar Mira, Kosnik Mitja, Korosec Peter
Abstract excerpt
BACKGROUND: Asthma is a common chronic disease characterized by airway inflammation and structural remodeling. Vascular endothelial growth factor (VEGF), a major regulator of angiogenesis, is elevated in asthma patients. VEGF contributes to airway responsiveness and remodeling. It has been shown that treatment of asthma patients decreases VEGF levels, and inhibition of VEGF diminishes asthma symptoms in mice....
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