Article
VEGFA variants are associated with pre-school lung function, but not neonatal lung function.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Nov 2013
Kreiner-Møller E, Chawes B L K, Vissing N H, Koppelman G H, Postma D S, Madsen J S, Olsen D A, Baty F, Vonk J M, Kerkhof M, Sleiman P, Hakonarsson H, Mortensen L J, Poorisrisak P, Bisgaard H, Bønnelykke K
Abstract excerpt
BACKGROUND: Vascular endothelial growth factor (VEGF) is implicated in airway remodelling and asthma development. We studied VEGFA gene variants and plasma levels and the development of lung function, bronchial hyperresponsiveness and asthma in childhood. METHODS: We analysed 13 SNPs in the VEGFA gene in 411 children from the COPSAC2000 high-risk birth cohort. Asthma was diagnosed prospectively, and lung function...
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