Article
Association of bone morphogenetic protein 4 gene polymorphisms with nonsyndromic cleft lip with or without cleft palate in Chinese children.
DNA and cell biology - 1 Nov 2008
Lin Jian-Yan, Chen Yong-Juan, Huang Yuan-lu, Tang Guang-Peng, Zhang Li, Deng Bing, Li Ming, Ma Hong, Luan Rong-Sheng
Abstract excerpt
Nonsyndromic cleft lip with or without cleft palate (nsCL/P) is one of the most common congenital anomalies in humans. The pathogenesis of nsCL/P involves both genetic and environmental factors. On the basis of linkage data suggesting that 14q21-24 is one of the chromosomal regions that affects nsCL/P and data locating the BMP4 gene to 14q22-23, we performed a case-control study to evaluate whether BMP4 538T/C...
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