Catechol-O-methyltransferase Val158 Met genotype, parenting practices and adolescent alcohol use: testing the differential susceptibility hypothesis.

doi:10.1111/j.1469-7610.2011.02408.x

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Article

Catechol-O-methyltransferase Val158 Met genotype, parenting practices and adolescent alcohol use: testing the differential susceptibility hypothesis.

Journal of child psychology and psychiatry, and allied disciplines - 1 Apr 2012

Laucht Manfred, Blomeyer Dorothea, Buchmann Arlette F, Treutlein Jens, Schmidt Martin H, Esser Günter, Jennen-Steinmetz Christine, Rietschel Marcella, Zimmermann Ulrich S, Banaschewski Tobias

Abstract excerpt

BACKGROUND: Recently, first evidence has been reported for a gene-parenting interaction (G × E) with regard to adolescent alcohol use. The present investigation set out to extend this research using the catechol-O-methyltransferase (COMT) Val(158) Met polymorphism as a genetic susceptibility factor. Moreover, the current study examined whether a potential G×E would be consistent with one of two models of...

Topics

Adolescent
Adolescent Behavior
Adult
Alcohol Drinking
Catechol O-Methyltransferase
Cohort Studies
Female
Genetic Predisposition to Disease
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Longitudinal Studies

Male

Parenting

Polymorphism, Genetic

Risk Factors

Valine

Young Adult

Source

Open in PubMed

Identifiers

PMID: 21501166
DOI: 10.1111/j.1469-7610.2011.02408.x

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Catechol-O-methyltransferase Val158 Met genotype, parenting practices and adolescent alcohol use: testing the differential susceptibility hypothesis.PMID 21501166Read ↗

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Physical and verbal aggressive behavior and COMT genotype: Sensitivity to the environment.Semantic proximity Read ↗

COMT Val158Met modulates the effect of childhood adverse experiences on the risk of alcohol dependence.Semantic proximity Read ↗

Early‐Life Adversity and Blunted Stress Reactivity as Predictors of Alcohol and Drug use in Persons With COMT (rs4680) Val158Met GenotypesSemantic proximity Read ↗

Monoamine Oxidase A (MAOA) and Catechol-O-Methyltransferase (COMT) Gene Polymorphisms Interact with Maternal Parenting in Association with Adolescent Reactive Aggression but not Proactive Aggression: Evidence of Differential Susceptibility.Semantic proximity Read ↗

Child exposure to serious life events, COMT, and aggression: Testing differential susceptibility theory.Semantic proximity Read ↗

Interactions between the COMT Val108/158Met polymorphism and maternal prenatal smoking predict aggressive behavior outcomes.Semantic proximity Read ↗

Interactions among catechol-O-methyltransferase genotype, parenting, and sex predict children's internalizing symptoms and inhibitory control: Evidence for differential susceptibility.Semantic proximity Read ↗

Preliminary evidence for a gene-environment interaction in predicting alcohol use disorders in adolescents.Semantic proximity Read ↗

Attention-deficit/hyperactivity disorder phenotype is influenced by a functional catechol-O-methyltransferase variant.Semantic proximity Read ↗

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