Article
Genetic susceptibility to Kawasaki disease: analysis of pattern recognition receptor genes.
Human immunology - 1 Jun 2012
Onoyama Sagano, Ihara Kenji, Yamaguchi Yui, Ikeda Kazuyuki, Yamaguchi Kenichiro, Yamamura Kenichiro, Hoshina Takayuki, Mizuno Yumi, Hara Toshiro
Abstract excerpt
Kawasaki disease (KD) is a systemic vasculitis of unknown etiology occurring in infants and children. Several lines of evidence suggested the importance of genetic factors and infectious triggers for the pathogenesis of KD. We have reported that oral administration of a pure NOD1 ligand induces coronary arteritis in mice without fail. Since NOD1 is one of the pattern recognition receptors (PRRs) which play...
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