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Article

Promoter region polymorphisms in the transforming growth factor beta-1 (TGFβ1) gene and serum TGFβ1 concentration in preeclamptic and control Iranian women.

Journal of reproductive immunology - 1 Jun 2012

Feizollahzadeh Sadegh, Taheripanah Robabeh, Khani Masood, Farokhi Babak, Amani Dawar

Abstract excerpt

Preeclampsia (PE) is a pregnancy associated disorder characterized by hypertension and proteinuria, which causes neonatal and maternal morbidity and mortality. The Th1/Th2 cytokine paradigm of the immune adaptation in pregnancy is now expanded to include Th1/Th2/Th17 and regulatory T (Treg) cells. Among cytokines, TGFβ1 has properties that justify evaluation of its role in PE etiopathology. In this investigation...

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PMID: 22503347
DOI: 10.1016/j.jri.2012.02.006

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