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Article

Molecular analysis of the Noggin (NOG) gene in holoprosencephaly patients.

Molecular genetics and metabolism - 1 Jun 2012

Srivastava Kshitij, Hu Ping, Solomon Benjamin D, Ming Jeffrey E, Roessler Erich, Muenke Maximilian

Abstract excerpt

Holoprosencephaly (HPE) is the most common structural anomaly of the human forebrain. Various genetic and teratogenic causes have been implicated in its pathogenesis. A recent report in mice described Noggin (NOG) as a candidate gene involved in the etiogenesis of microform HPE. Here, we present for the first time genetic analysis of a large HPE cohort for sequence variations in NOG. On the basis of our study, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22503063
DOI: 10.1016/j.ymgme.2012.03.008
PMCID: PMC3356444

Genes

NOG

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