Article
Schedule dependence for cisplatin and etoposide multifraction treatments of spheroids.
Journal of the National Cancer Institute - 5 Dec 1990
Durand R E, Vanderbyl S L
Abstract excerpt
Cisplatin and etoposide are both widely used as antineoplastic chemotherapeutic agents. Two approaches are generally adopted when an attempt is made to maximize the efficiency of these drugs: concurrent use (where synergism is expected) or sequential administrations (exploiting the antiproliferative effects of etoposide). To differentiate between these approaches in a quantitative manner, we exposed an in vitro...
Topics
- Animals
- Cell Division
- Cell Survival
- Cisplatin
- Cricetinae
- Cricetulus
- Culture Techniques
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Drug Resistance
- Etoposide