Article
Three novel alleles in the Kell blood group system resulting in the Knull phenotype and the first in a Native American.
Transfusion - 1 Nov 2013
Moulds Joann M, Persa Rosemary, Rierson Darbi, Billingsley Katrina L, Noumsi Ghislain T, Hue-Roye Kim, Reid Marion E
Abstract excerpt
BACKGROUND: Antibodies to Kell antigens can be clinically important but only limited data are published regarding anti-Ku. Missense nucleotide changes in KEL account for the numerous Kell antigens, the K(mod) phenotype, and even the K(null) phenotype. STUDY DESIGN AND METHODS: DNA and RNA were extracted from white blood cells and polymerase chain reaction-based assays, cloning, and sequencing were done using...
Topics
- Adult
- Alleles
- Erythroblastosis, Fetal
- Female
- Gene Silencing
- Humans
- Indians, North American
- Infant, Newborn
- Kell Blood-Group System
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation, Missense
- Phenotype
- Pregnancy