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Article

The interaction between the maternal BMI and angiogenic gene polymorphisms associates with the risk of spontaneous preterm birth.

Molecular human reproduction - 1 Sept 2012

Andraweera Prabha H, Dekker Gustaaf A, Thompson Steven D, North Robyn A, McCowan Lesley M E, Roberts Claire T

Abstract excerpt

Obesity is associated with an increased level of inflammation. Interactions between inflammatory and angiogenic pathways are implicated in the major pregnancy disorders. The aim of this study was to investigate whether functional polymorphisms in angiogenesis-regulating genes (VEGFA rs699947, VEGFA rs3025039, KDR rs2071559 and ANGPT1 rs2507800) interact with the maternal BMI to modify the risk of a spontaneous...

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Topics

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Share to Angiopoietin-1
Share to Body Mass Index
Share to Inflammation
Share to Neovascularization, Physiologic
Share to Pregnancy Complications
Share to Premature Birth
Share to Vascular Endothelial Growth Factor A
Share to Vascular Endothelial Growth Factor Receptor-2

Source

Identifiers

PMID: 22491902
DOI: 10.1093/molehr/gas016

Genes

VEGFA
ANGPT1
KDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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