Article
Genome-wide approach identifies a novel gene-maternal pre-pregnancy BMI interaction on preterm birth.
Nature communications - 9 Jun 2017
Hong Xiumei, Hao Ke, Ji Hongkai, Peng Shouneng, Sherwood Ben, Di Narzo Antonio, Tsai Hui-Ju, Liu Xin, Burd Irina, Wang Guoying, Ji Yuelong, Caruso Deanna, Mao Guangyun, Bartell Tami R, Zhang Zhongyang, Pearson Colleen, Heffner Linda, Cerda Sandra, Beaty Terri H, Fallin M Daniele, Lee-Parritz Aviva, Zuckerman Barry, Weeks Daniel E, Wang Xiaobin
Abstract excerpt
Preterm birth (PTB) contributes significantly to infant mortality and morbidity with lifelong impact. Few robust genetic factors of PTB have been identified. Such 'missing heritability' may be partly due to gene × environment interactions (G × E), which is largely unexplored. Here we conduct genome-wide G × E analyses of PTB in 1,733 African-American women (698 mothers of PTB; 1,035 of term birth) from the Boston...
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