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Identical twins with Leucine rich repeat kinase type 2 mutations discordant for Parkinson's disease

4 Apr 2012

Abstract excerpt

Analysis of concordancy rates in monozygotic and dizygotic twins with Parkinson's disease (PD) has been an important subject for research into the disorder1 and discordancy between twins has traditionally been interpreted as evidence against a genetic etiology of disease. Discordancy in late-onset diseases such as PD is complicated by the possibility that the disease onset may vary considerably between twins, and...

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PMID: 22488887
DOI: 10.1002/mds.24924

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