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Article

Heterogeneity of high-grade cervical intraepithelial neoplasia related to HPV16: implications for natural history and management.

International journal of cancer - 1 Jan 2013

Wentzensen Nicolas, Walker Joan, Schiffman Mark, Yang Hannah P, Zuna Rosemary E, Dunn S Terence, Allen R Andy, Zhang Roy, Sherman Mark, Gold Michael A, Wang Sophia S

Abstract excerpt

Factors associated with progression from cervical intraepithelial neoplasia (CIN) grades 2 and 3 to invasive cancer are not well understood; most CIN2 and CIN3 do not progress to cancer. Among carcinogenic human papillomavirus (HPV) types, infections with HPV16 have the highest risk of progressing to cancer. We evaluated the heterogeneity of risk factors, lesion size, colposcopic impression and colposcopic biopsy...

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Source

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Identifiers

PMID: 22488167
DOI: 10.1002/ijc.27577
PMCID: PMC3409928

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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