Article
CK2-defective Arabidopsis plants exhibit enhanced double-strand break repair rates and reduced survival after exposure to ionizing radiation.
The Plant journal : for cell and molecular biology - 1 Aug 2012
Moreno-Romero Jordi, Armengot Laia, Mar Marquès-Bueno M, Britt Anne, Carmen Martínez M
Abstract excerpt
The multifunctional protein kinase CK2 is involved in several aspects of the DNA damage response (DDR) in mammals. To gain insight into the role of CK2 in plant genome maintenance, we studied the response to genotoxic agents of an Arabidopsis CK2 dominant-negative mutant (CK2mut plants). CK2mut plants were hypersensitive to a wide range of genotoxins that produce a variety of DNA lesions. However, they were able...
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