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Article

Interindividual concordance of methylation profiles in human genes for tumor necrosis factors alpha and beta.

1 Nov 1990

Abstract excerpt

The DNA in mammalian genomes is characterized by complex patterns of DNA methylation that reflect the states of all genetic activities of that genome. The modified nucleotide 5-methyldeoxycytidine (5mdC) can affect the interactions of specific proteins with DNA sequence motifs. The most extensively studied effect of sequence-specific methylations is that of the long-term silencing of eukaryotic (mammalian)...

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PMID: 2247453
DOI: 10.1073/pnas.87.22.8830

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