Gemfibrozil is a strong inactivator of CYP2C8 in very small multiple doses.

Abstract excerpt

Therapeutic doses of gemfibrozil cause mechanism-based inactivation of CYP2C8 via formation of gemfibrozil 1-O-β-glucuronide. We investigated the extent of CYP2C8 inactivation caused by three different doses of gemfibrozil twice dailyfor 5 days, using repaglinide as a probe drug, in 10 healthy volunteers. At the end of this 5-day regimen, there were dose-dependent increases in the area under the plasma...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Area Under Curve
• Share to Carbamates
• Share to Cross-Over Studies