Article
Exploiting adaptive laboratory evolution of Streptomyces clavuligerus for antibiotic discovery and overproduction.
PloS one - 1 Jan 2012
Charusanti Pep, Fong Nicole L, Nagarajan Harish, Pereira Alban R, Li Howard J, Abate Elisa A, Su Yongxuan, Gerwick William H, Palsson Bernhard O
Abstract excerpt
Adaptation is normally viewed as the enemy of the antibiotic discovery and development process because adaptation among pathogens to antibiotic exposure leads to resistance. We present a method here that, in contrast, exploits the power of adaptation among antibiotic producers to accelerate the discovery of antibiotics. A competition-based adaptive laboratory evolution scheme is presented whereby an...
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