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Article

Hierarchical genetic organization of human cortical surface area.

Science (New York, N.Y.) - 30 Mar 2012

Chen Chi-Hua, Gutierrez E D, Thompson Wes, Panizzon Matthew S, Jernigan Terry L, Eyler Lisa T, Fennema-Notestine Christine, Jak Amy J, Neale Michael C, Franz Carol E, Lyons Michael J, Grant Michael D, Fischl Bruce, Seidman Larry J, Tsuang Ming T, Kremen William S, Dale Anders M

Abstract excerpt

Surface area of the cerebral cortex is a highly heritable trait, yet little is known about genetic influences on regional cortical differentiation in humans. Using a data-driven, fuzzy clustering technique with magnetic resonance imaging data from 406 twins, we parceled cortical surface area into genetic subdivisions, creating a human brain atlas based solely on genetically informative data. Boundaries of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22461613
DOI: 10.1126/science.1215330
PMCID: PMC3690329

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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